Pilot Projects

Pilot Projects

CGAPS aims to use findings from gene-environment (G-E) interplay, developmental, and epigenetic research as the basis for transformations of etiologic models of drug abuse and sexual risk behavior that increase their predictive utility and the efficacy of the prevention programs they inform.

Funding of pilot projects is intended to provide resources and intellectual support for investigators to conduct feasibility studies and secondary data analyses that advance CGAPS research initiatives. Please contact CGAPS if you are a researcher interested in learning about or pursuing substance use-related research that addresses the transactions of family and community environments with genetic and epigenetic factors.

Center for Contextual Genetics and Prevention Science / Center for the Study of Gene-Social Environment Transactions (C-GSET) Projects

Genetic, Environmental, and Psychosocial Factors Associated with Teens' Non-responsiveness to HIV Intervention

Dr. Sales proposed research is designed to identify potential genetic factors directly associated with adolescents’ failure to change their HIV-associated sex behavior.

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Effects of Alcohol and Drugs on the Human Stress Response

Dr. Obasi is studying the impact that substance abuse has on health disparities for at-risk African Americans.

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Behavioral and Physiological Mother-Child Synchrony as a Moderator of Genetic Risk in a Preschool Sample

The current study proposes to examine the genetic underpinnings of parent-child mutual reactivity.

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Novel Neuroeconomic Intermediate Phenotypes For Nicotine Dependence: A Pilot Study

The proposed study will assess cigarette demand using functional magnetic resonance imaging for the first time.

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Utilizing Cell Lines to Examine the Role of African Americans’ Substance Use History, Negative Life Events, Poverty, and Racial Discrimination in Epigenetic Programming

The purpose of this study is to determine the relation of methylation of Monoamine Oxidase A (MAOA) and the serotonin transporter (5HTT) to behavioral outcomes including, delayed discounting and substance abuse in young, African American adults.

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The Impact of Family-Based Preventive Interventions on Genetic Diatheses for Drug Use

Investigators propose to investigate the moderating influence of family-based substance use.

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Contribution of Self-Control Processes and Genetic Influences on Drug Use Phenotypes

Researchers in this study will conduct investigations of a potential intermediate phenotype, self-control processes, which may refine understanding of how genetic vulnerabilities are linked to the initiation and escalation of drug use during adolescence.

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Psychological, Substance Use, and Genetic Factors in Persistent Suicide Ideation among African American and European American Adolescents

The current study will examine the confluence of psychological and psychiatric factors, substance use behavior, and genetic markers associated with persistent suicide ideation in African American and European American adolescents.

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Genetic Susceptibility, Stress, and Parenting in African American Mothers of Preterm Infants

The goal of this study is to explore the role of gene-environment interaction in parenting efficacy among African American mothers who recently give birth to a preterm infant hospitalized in the Neonatal Intensive Care Unit (NICU).

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Linking Genotypes and Social Relationships to Health: A Study of African Americans

The proposed study will investigate how social relationships and genotypes additively and multiplicatively influence substance use, mental health and physical health of African American men.

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Genetic Basis of Impulsivity and Related Phenotypes in Pathological Gambling

The proposed study will examine the relationship between genetic variation in genes responsible for dopamine neurotransmission and delayed reward discounting (DRD).

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Exploring Genotype and Methylation Status in Relation to Substance Use and Life Stress

Young adult participants from the Adults in the Making (AIM) study are recruited for blood sample analyses. These data will be integrated with previous wave data to explore questions related to the moderation of effects of particular genotypes.

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Allostatic Load and Genetic Variation Among Rural African American Young Adults and Primary Caregivers

200 young African American young adults and their primary caregivers will complete a third wave home assessment as part of a longitudinal study. This study will be expanded to test hypotheses related to allostatic load and genetic risk.

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Birmingham Youth Violence Study

The BYVS is a longitudinal study of youth that focuses on precursors, correlates, and consequences of dating violence within a multilevel developmental framework.

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Gene x Environment Interactions Influencing Smoking Among African American Females

This study aims to indentify and explore interactions associated with genetic, psychosocial, behavioral and environmental factors associated with young adult African American females and smoking.

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African American Men's Project (AMP)

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Center for the Study of Gene-Social Environment Transactions (C-GSET)

DID YOU KNOW?

Epigenomics is the study of global analyses of epigenetic changes across the entire genome.